Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites.
Identifieur interne : 000043 ( Main/Exploration ); précédent : 000042; suivant : 000044Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites.
Auteurs : Yan-Hu Liu [République populaire de Chine] ; Lu Wang [République populaire de Chine] ; Tao Xu [République populaire de Chine] ; Xiaomin Guo [République populaire de Chine] ; Yang Li [République populaire de Chine] ; Ting-Ting Yin [République populaire de Chine] ; He-Chuan Yang [Singapour] ; Hu Yang [République populaire de Chine] ; Adeniyi C. Adeola [République populaire de Chine] ; Oscar J Sanke [Nigeria] ; Newton O Otecko [République populaire de Chine] ; Meng Wang [République populaire de Chine] ; Yaping Ma [République populaire de Chine] ; Olaogun S Charles [Nigeria] ; Mikkel-Holger S Sinding [Danemark] ; Shyam Gopalakrishnan [Danemark] ; José Alfredo Samaniego [Danemark] ; Anders J. Hansen [Danemark] ; Carlos Fernandes [Portugal] ; Philippe Gaubert [France] ; Jane Budd [Émirats arabes unis] ; Philip M Dawuda [Nigeria] ; Eli Knispel Rueness [Norvège] ; Lubin Jiang [République populaire de Chine] ; Weiwei Zhai [Singapour] ; M T P. Gilbert [Danemark] ; Min-Sheng Peng [République populaire de Chine] ; Xiaopeng Qi [République populaire de Chine] ; Guo-Dong Wang [République populaire de Chine] ; Ya-Ping Zhang [République populaire de Chine]Source :
- Molecular biology and evolution [ 1537-1719 ] ; 2017.
Abstract
Natural selection in domestic dogs is of great interest in evolutionary biology since dogs have migrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. Here, we explored their demographic history and genetic basis of adaptation to the tropical African environment using whole genome analyses of 19 African indigenous dogs from Nigeria. Demographic analysis suggests that the ancestors of these dogs migrated into Africa from Eurasia 14,000 years ago and underwent a severe founder effect before population expansion. Admixture analysis further reveals that African dog genomes contain about 1.88%-3.50% introgression from African golden wolves (Canis anthus). Population genetic analysis identifies 50 positively selected genes linked with immunity, angiogenesis, ultraviolet protection, as well as insulin secretion and sensitivity that may contribute to adaptation to tropical conditions. One of the positively selected genes, ADGRE1 (adhesion G protein-coupled receptor E1), has also been found to be association with severe malaria resistance in African human populations. Functional assessments showed that ADGRE1 provides protective host defense against Plasmodium infections. This result, together with the fact that the inflammatory response to canine babesiosis is similar to complicated falciparum malaria in humans, support the dogs as a model for the study of malaria control and treatment.
DOI: 10.1093/molbev/msx258
PubMed: 29040727
Affiliations:
- Danemark, France, Nigeria, Norvège, Portugal, République populaire de Chine, Singapour, Émirats arabes unis
- Hovedstaden, État d'Oyo
- Copenhague, Ibadan
- Université d'Ibadan
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nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Samaniego, Jose Alfredo" sort="Samaniego, Jose Alfredo" uniqKey="Samaniego J" first="José Alfredo" last="Samaniego">José Alfredo Samaniego</name><affiliation wicri:level="1"><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Hansen, Anders J" sort="Hansen, Anders J" uniqKey="Hansen A" first="Anders J" last="Hansen">Anders J. Hansen</name><affiliation wicri:level="1"><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Fernandes, Carlos" sort="Fernandes, Carlos" uniqKey="Fernandes C" first="Carlos" last="Fernandes">Carlos Fernandes</name><affiliation wicri:level="1"><nlm:affiliation>CE3C - Centre for Ecology, Evolution and Environmental Changes, Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>CE3C - Centre for Ecology, Evolution and Environmental Changes, Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa</wicri:regionArea><wicri:noRegion>1749-016 Lisboa</wicri:noRegion></affiliation></author><author><name sortKey="Gaubert, Philippe" sort="Gaubert, Philippe" uniqKey="Gaubert P" first="Philippe" last="Gaubert">Philippe Gaubert</name><affiliation wicri:level="1"><nlm:affiliation>Institut des Sciences de l'Evolution de Montpellier (ISEM) - UM-CNRS-IRD-EPHE, Université de Montpellier, Place Eugène Bataillon - CC 64, 34095 Montpellier cedex 05,France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut des Sciences de l'Evolution de Montpellier (ISEM) - UM-CNRS-IRD-EPHE, Université de Montpellier, Place Eugène Bataillon - CC 64, 34095 Montpellier cedex 05</wicri:regionArea><wicri:noRegion>34095 Montpellier cedex 05</wicri:noRegion><wicri:noRegion>34095 Montpellier cedex 05</wicri:noRegion></affiliation></author><author><name sortKey="Budd, Jane" sort="Budd, Jane" uniqKey="Budd J" first="Jane" last="Budd">Jane Budd</name><affiliation wicri:level="1"><nlm:affiliation>Breeding Centre for Endangered Arabian Wildlife, PO Box 29922, Sharjah, United Arab Emirates.</nlm:affiliation><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Breeding Centre for Endangered Arabian Wildlife, PO Box 29922, Sharjah</wicri:regionArea><wicri:noRegion>Sharjah</wicri:noRegion></affiliation></author><author><name sortKey="M Dawuda, Philip" sort="M Dawuda, Philip" uniqKey="M Dawuda P" first="Philip" last="M Dawuda">Philip M Dawuda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, University of Agriculture Makurdi, Benue State, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, University of Agriculture Makurdi, Benue State</wicri:regionArea><wicri:noRegion>Benue State</wicri:noRegion></affiliation></author><author><name sortKey="Rueness, Eli Knispel" sort="Rueness, Eli Knispel" uniqKey="Rueness E" first="Eli Knispel" last="Rueness">Eli Knispel Rueness</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Ecological and Evolutionary Synthesis (CEES), Dept. of Biosciences, University of Oslo, PO Box 1166 Blindern, N-0316 Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Centre for Ecological and Evolutionary Synthesis (CEES), Dept. of Biosciences, University of Oslo, PO Box 1166 Blindern, N-0316 Oslo</wicri:regionArea><wicri:noRegion>N-0316 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Lubin" sort="Jiang, Lubin" uniqKey="Jiang L" first="Lubin" last="Jiang">Lubin Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai 200031, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Zhai, Weiwei" sort="Zhai, Weiwei" uniqKey="Zhai W" first="Weiwei" last="Zhai">Weiwei Zhai</name><affiliation wicri:level="1"><nlm:affiliation>Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome #02-01, 138672, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome #02-01, 138672</wicri:regionArea><wicri:noRegion>138672</wicri:noRegion></affiliation></author><author><name sortKey="Gilbert, M T P" sort="Gilbert, M T P" uniqKey="Gilbert M" first="M T P" last="Gilbert">M T P. Gilbert</name><affiliation wicri:level="1"><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Peng, Min Sheng" sort="Peng, Min Sheng" uniqKey="Peng M" first="Min-Sheng" last="Peng">Min-Sheng Peng</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223</wicri:regionArea><wicri:noRegion>650223</wicri:noRegion></affiliation></author><author><name sortKey="Qi, Xiaopeng" sort="Qi, Xiaopeng" uniqKey="Qi X" first="Xiaopeng" last="Qi">Xiaopeng Qi</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Guo Dong" sort="Wang, Guo Dong" uniqKey="Wang G" first="Guo-Dong" last="Wang">Guo-Dong Wang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223</wicri:regionArea><wicri:noRegion>650223</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Ya Ping" sort="Zhang, Ya Ping" uniqKey="Zhang Y" first="Ya-Ping" last="Zhang">Ya-Ping Zhang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29040727</idno><idno type="pmid">29040727</idno><idno type="doi">10.1093/molbev/msx258</idno><idno type="wicri:Area/PubMed/Corpus">000372</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000372</idno><idno type="wicri:Area/PubMed/Curation">000370</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000370</idno><idno type="wicri:Area/PubMed/Checkpoint">000370</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" 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Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Lu" sort="Wang, Lu" uniqKey="Wang L" first="Lu" last="Wang">Lu Wang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Tao" sort="Xu, Tao" uniqKey="Xu T" first="Tao" last="Xu">Tao Xu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Xiaomin" sort="Guo, Xiaomin" uniqKey="Guo X" first="Xiaomin" last="Guo">Xiaomin Guo</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yang" sort="Li, Yang" uniqKey="Li Y" first="Yang" last="Li">Yang Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Yin, Ting Ting" sort="Yin, Ting Ting" uniqKey="Yin T" first="Ting-Ting" last="Yin">Ting-Ting Yin</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223</wicri:regionArea><wicri:noRegion>650223</wicri:noRegion></affiliation></author><author><name sortKey="Yang, He Chuan" sort="Yang, He Chuan" uniqKey="Yang H" first="He-Chuan" last="Yang">He-Chuan Yang</name><affiliation wicri:level="1"><nlm:affiliation>Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome #02-01, 138672, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome #02-01, 138672</wicri:regionArea><wicri:noRegion>138672</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Hu" sort="Yang, Hu" uniqKey="Yang H" first="Hu" last="Yang">Hu Yang</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai 200031, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Adeola, Adeniyi C" sort="Adeola, Adeniyi C" uniqKey="Adeola A" first="Adeniyi C" last="Adeola">Adeniyi C. Adeola</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223</wicri:regionArea><wicri:noRegion>650223</wicri:noRegion></affiliation></author><author><name sortKey="J Sanke, Oscar" sort="J Sanke, Oscar" uniqKey="J Sanke O" first="Oscar" last="J Sanke">Oscar J Sanke</name><affiliation wicri:level="1"><nlm:affiliation>Taraba State Ministry of Agriculture and Natural Resources, Jalingo, Taraba State, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Taraba State Ministry of Agriculture and Natural Resources, Jalingo, Taraba State</wicri:regionArea><wicri:noRegion>Taraba State</wicri:noRegion></affiliation></author><author><name sortKey="O Otecko, Newton" sort="O Otecko, Newton" uniqKey="O Otecko N" first="Newton" last="O Otecko">Newton O Otecko</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223</wicri:regionArea><wicri:noRegion>650223</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Meng" sort="Wang, Meng" uniqKey="Wang M" first="Meng" last="Wang">Meng Wang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Yaping" sort="Ma, Yaping" uniqKey="Ma Y" first="Yaping" last="Ma">Yaping Ma</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="S Charles, Olaogun" sort="S Charles, Olaogun" uniqKey="S Charles O" first="Olaogun" last="S Charles">Olaogun S Charles</name><affiliation wicri:level="4"><nlm:affiliation>Department of Veterinary Medicine, University of Ibadan, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Veterinary Medicine, University of Ibadan</wicri:regionArea><placeName><settlement type="city">Ibadan</settlement><region type="region">État d'Oyo</region></placeName><orgName type="university">Université d'Ibadan</orgName></affiliation></author><author><name sortKey="S Sinding, Mikkel Holger" sort="S Sinding, Mikkel Holger" uniqKey="S Sinding M" first="Mikkel-Holger" last="S Sinding">Mikkel-Holger S Sinding</name><affiliation wicri:level="1"><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Gopalakrishnan, Shyam" sort="Gopalakrishnan, Shyam" uniqKey="Gopalakrishnan S" first="Shyam" last="Gopalakrishnan">Shyam Gopalakrishnan</name><affiliation wicri:level="1"><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Samaniego, Jose Alfredo" sort="Samaniego, Jose Alfredo" uniqKey="Samaniego J" first="José Alfredo" last="Samaniego">José Alfredo Samaniego</name><affiliation wicri:level="1"><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Hansen, Anders J" sort="Hansen, Anders J" uniqKey="Hansen A" first="Anders J" last="Hansen">Anders J. Hansen</name><affiliation wicri:level="1"><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Fernandes, Carlos" sort="Fernandes, Carlos" uniqKey="Fernandes C" first="Carlos" last="Fernandes">Carlos Fernandes</name><affiliation wicri:level="1"><nlm:affiliation>CE3C - Centre for Ecology, Evolution and Environmental Changes, Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>CE3C - Centre for Ecology, Evolution and Environmental Changes, Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa</wicri:regionArea><wicri:noRegion>1749-016 Lisboa</wicri:noRegion></affiliation></author><author><name sortKey="Gaubert, Philippe" sort="Gaubert, Philippe" uniqKey="Gaubert P" first="Philippe" last="Gaubert">Philippe Gaubert</name><affiliation wicri:level="1"><nlm:affiliation>Institut des Sciences de l'Evolution de Montpellier (ISEM) - UM-CNRS-IRD-EPHE, Université de Montpellier, Place Eugène Bataillon - CC 64, 34095 Montpellier cedex 05,France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut des Sciences de l'Evolution de Montpellier (ISEM) - UM-CNRS-IRD-EPHE, Université de Montpellier, Place Eugène Bataillon - CC 64, 34095 Montpellier cedex 05</wicri:regionArea><wicri:noRegion>34095 Montpellier cedex 05</wicri:noRegion><wicri:noRegion>34095 Montpellier cedex 05</wicri:noRegion></affiliation></author><author><name sortKey="Budd, Jane" sort="Budd, Jane" uniqKey="Budd J" first="Jane" last="Budd">Jane Budd</name><affiliation wicri:level="1"><nlm:affiliation>Breeding Centre for Endangered Arabian Wildlife, PO Box 29922, Sharjah, United Arab Emirates.</nlm:affiliation><country xml:lang="fr">Émirats arabes unis</country><wicri:regionArea>Breeding Centre for Endangered Arabian Wildlife, PO Box 29922, Sharjah</wicri:regionArea><wicri:noRegion>Sharjah</wicri:noRegion></affiliation></author><author><name sortKey="M Dawuda, Philip" sort="M Dawuda, Philip" uniqKey="M Dawuda P" first="Philip" last="M Dawuda">Philip M Dawuda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, University of Agriculture Makurdi, Benue State, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, University of Agriculture Makurdi, Benue State</wicri:regionArea><wicri:noRegion>Benue State</wicri:noRegion></affiliation></author><author><name sortKey="Rueness, Eli Knispel" sort="Rueness, Eli Knispel" uniqKey="Rueness E" first="Eli Knispel" last="Rueness">Eli Knispel Rueness</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Ecological and Evolutionary Synthesis (CEES), Dept. of Biosciences, University of Oslo, PO Box 1166 Blindern, N-0316 Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Centre for Ecological and Evolutionary Synthesis (CEES), Dept. of Biosciences, University of Oslo, PO Box 1166 Blindern, N-0316 Oslo</wicri:regionArea><wicri:noRegion>N-0316 Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Lubin" sort="Jiang, Lubin" uniqKey="Jiang L" first="Lubin" last="Jiang">Lubin Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai 200031, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institut Pasteur of Shanghai, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Zhai, Weiwei" sort="Zhai, Weiwei" uniqKey="Zhai W" first="Weiwei" last="Zhai">Weiwei Zhai</name><affiliation wicri:level="1"><nlm:affiliation>Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome #02-01, 138672, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Human Genetics, Genome Institute of Singapore, A*STAR, 60 Biopolis Street, Genome #02-01, 138672</wicri:regionArea><wicri:noRegion>138672</wicri:noRegion></affiliation></author><author><name sortKey="Gilbert, M T P" sort="Gilbert, M T P" uniqKey="Gilbert M" first="M T P" last="Gilbert">M T P. Gilbert</name><affiliation wicri:level="1"><nlm:affiliation>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Natural History Museum of Denmark, Øster Voldgade 5-7, 1350 Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Peng, Min Sheng" sort="Peng, Min Sheng" uniqKey="Peng M" first="Min-Sheng" last="Peng">Min-Sheng Peng</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223</wicri:regionArea><wicri:noRegion>650223</wicri:noRegion></affiliation></author><author><name sortKey="Qi, Xiaopeng" sort="Qi, Xiaopeng" uniqKey="Qi X" first="Xiaopeng" last="Qi">Xiaopeng Qi</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming, 650223, Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Guo Dong" sort="Wang, Guo Dong" uniqKey="Wang G" first="Guo-Dong" last="Wang">Guo-Dong Wang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Resources and Evolution, and Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223</wicri:regionArea><wicri:noRegion>650223</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Ya Ping" sort="Zhang, Ya Ping" uniqKey="Zhang Y" first="Ya-Ping" last="Zhang">Ya-Ping Zhang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, and School of Life Sciences, Yunnan University, Kunming, 650091,Yunnan</wicri:regionArea><wicri:noRegion>Yunnan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular biology and evolution</title><idno type="eISSN">1537-1719</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Natural selection in domestic dogs is of great interest in evolutionary biology since dogs have migrated to every inhabited continent of the world alongside humans, and adapted to diverse environments. Here, we explored their demographic history and genetic basis of adaptation to the tropical African environment using whole genome analyses of 19 African indigenous dogs from Nigeria. Demographic analysis suggests that the ancestors of these dogs migrated into Africa from Eurasia 14,000 years ago and underwent a severe founder effect before population expansion. Admixture analysis further reveals that African dog genomes contain about 1.88%-3.50% introgression from African golden wolves (Canis anthus). Population genetic analysis identifies 50 positively selected genes linked with immunity, angiogenesis, ultraviolet protection, as well as insulin secretion and sensitivity that may contribute to adaptation to tropical conditions. One of the positively selected genes, ADGRE1 (adhesion G protein-coupled receptor E1), has also been found to be association with severe malaria resistance in African human populations. Functional assessments showed that ADGRE1 provides protective host defense against Plasmodium infections. This result, together with the fact that the inflammatory response to canine babesiosis is similar to complicated falciparum malaria in humans, support the dogs as a model for the study of malaria control and treatment.</div></front></TEI><affiliations><list><country><li>Danemark</li><li>France</li><li>Nigeria</li><li>Norvège</li><li>Portugal</li><li>République populaire de Chine</li><li>Singapour</li><li>Émirats arabes unis</li></country><region><li>Hovedstaden</li><li>État d'Oyo</li></region><settlement><li>Copenhague</li><li>Ibadan</li></settlement><orgName><li>Université d'Ibadan</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Yan Hu" sort="Liu, Yan Hu" uniqKey="Liu Y" first="Yan-Hu" last="Liu">Yan-Hu Liu</name></noRegion><name sortKey="Adeola, Adeniyi C" sort="Adeola, Adeniyi C" uniqKey="Adeola A" first="Adeniyi C" last="Adeola">Adeniyi C. Adeola</name><name sortKey="Guo, Xiaomin" sort="Guo, Xiaomin" uniqKey="Guo X" first="Xiaomin" last="Guo">Xiaomin Guo</name><name sortKey="Jiang, Lubin" sort="Jiang, Lubin" uniqKey="Jiang L" first="Lubin" last="Jiang">Lubin Jiang</name><name sortKey="Li, Yang" sort="Li, Yang" uniqKey="Li Y" first="Yang" last="Li">Yang Li</name><name sortKey="Ma, Yaping" sort="Ma, Yaping" uniqKey="Ma Y" first="Yaping" last="Ma">Yaping Ma</name><name sortKey="O Otecko, Newton" sort="O Otecko, Newton" uniqKey="O Otecko N" first="Newton" last="O Otecko">Newton O Otecko</name><name sortKey="Peng, Min Sheng" sort="Peng, Min Sheng" uniqKey="Peng M" first="Min-Sheng" last="Peng">Min-Sheng Peng</name><name sortKey="Qi, Xiaopeng" sort="Qi, Xiaopeng" uniqKey="Qi X" first="Xiaopeng" last="Qi">Xiaopeng Qi</name><name sortKey="Wang, Guo Dong" sort="Wang, Guo Dong" uniqKey="Wang G" first="Guo-Dong" last="Wang">Guo-Dong Wang</name><name sortKey="Wang, Lu" sort="Wang, Lu" uniqKey="Wang L" first="Lu" last="Wang">Lu Wang</name><name sortKey="Wang, Meng" sort="Wang, Meng" uniqKey="Wang M" first="Meng" last="Wang">Meng Wang</name><name sortKey="Xu, Tao" sort="Xu, Tao" uniqKey="Xu T" first="Tao" last="Xu">Tao Xu</name><name sortKey="Yang, Hu" sort="Yang, Hu" uniqKey="Yang H" first="Hu" last="Yang">Hu Yang</name><name sortKey="Yin, Ting Ting" sort="Yin, Ting Ting" uniqKey="Yin T" first="Ting-Ting" last="Yin">Ting-Ting Yin</name><name sortKey="Zhang, Ya Ping" sort="Zhang, Ya Ping" uniqKey="Zhang Y" first="Ya-Ping" last="Zhang">Ya-Ping Zhang</name></country><country name="Singapour"><noRegion><name sortKey="Yang, He Chuan" sort="Yang, He Chuan" uniqKey="Yang H" first="He-Chuan" last="Yang">He-Chuan Yang</name></noRegion><name sortKey="Zhai, Weiwei" sort="Zhai, Weiwei" uniqKey="Zhai W" first="Weiwei" last="Zhai">Weiwei Zhai</name></country><country name="Nigeria"><noRegion><name sortKey="J Sanke, Oscar" sort="J Sanke, Oscar" uniqKey="J Sanke O" first="Oscar" last="J Sanke">Oscar J Sanke</name></noRegion><name sortKey="M Dawuda, Philip" sort="M Dawuda, Philip" uniqKey="M Dawuda P" first="Philip" last="M Dawuda">Philip M Dawuda</name><name sortKey="S Charles, Olaogun" sort="S Charles, Olaogun" uniqKey="S Charles O" first="Olaogun" last="S Charles">Olaogun S Charles</name></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="S Sinding, Mikkel Holger" sort="S Sinding, Mikkel Holger" uniqKey="S Sinding M" first="Mikkel-Holger" last="S Sinding">Mikkel-Holger S Sinding</name></region><name sortKey="Gilbert, M T P" sort="Gilbert, M T P" uniqKey="Gilbert M" first="M T P" last="Gilbert">M T P. Gilbert</name><name sortKey="Gopalakrishnan, Shyam" sort="Gopalakrishnan, Shyam" uniqKey="Gopalakrishnan S" first="Shyam" last="Gopalakrishnan">Shyam Gopalakrishnan</name><name sortKey="Hansen, Anders J" sort="Hansen, Anders J" uniqKey="Hansen A" first="Anders J" last="Hansen">Anders J. Hansen</name><name sortKey="Samaniego, Jose Alfredo" sort="Samaniego, Jose Alfredo" uniqKey="Samaniego J" first="José Alfredo" last="Samaniego">José Alfredo Samaniego</name></country><country name="Portugal"><noRegion><name sortKey="Fernandes, Carlos" sort="Fernandes, Carlos" uniqKey="Fernandes C" first="Carlos" last="Fernandes">Carlos Fernandes</name></noRegion></country><country name="France"><noRegion><name sortKey="Gaubert, Philippe" sort="Gaubert, Philippe" uniqKey="Gaubert P" first="Philippe" last="Gaubert">Philippe Gaubert</name></noRegion></country><country name="Émirats arabes unis"><noRegion><name sortKey="Budd, Jane" sort="Budd, Jane" uniqKey="Budd J" first="Jane" last="Budd">Jane Budd</name></noRegion></country><country name="Norvège"><noRegion><name sortKey="Rueness, Eli Knispel" sort="Rueness, Eli Knispel" uniqKey="Rueness E" first="Eli Knispel" last="Rueness">Eli Knispel Rueness</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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